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Literature summary extracted from

  • Rasimas, J.J.; Kar, S.R.; Pegg, A.E.; Fried, M.G.
    Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs (2007), J. Biol. Chem., 282, 3357-3366.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.63 molecular biology modest binding cooperativity and high binding densities of AGT are adaptations that allow the enzyme to efficiently search for lesions in the context of chromatin remodeling and DNA replication Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.63 21614
-
 x * 21860, SDS-PAGE, x * 21614, sequence analysis Homo sapiens
2.1.1.63 21860
-
 x * 21860, SDS-PAGE, x * 21614, sequence analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens P16455
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.63 to apparent homogeneity Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.1.1.63 -80°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 additional information binding of AGT to single-stranded DNAs ranging in length from 5 to 78 nucleotides, binding is moderately cooperative, resulting in an all-or-nothing association pattern on short templates binding density Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.63 ? x * 21860, SDS-PAGE, x * 21614, sequence analysis Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 AGT
-
 Homo sapiens
2.1.1.63 O6-alkylguanine-DNA alkyltransferase
-
 Homo sapiens